反应详情

A mixture of cyanuric chloride (75 mg, 0.407 mmol, 1 equivalent) in CH3CN/H2O (1/1, 5 ml) was cooled to 0° C. (R)-(+)-beta-methylphenethylamine (55 mg, 0.407 mmol, 1 equivalent) was added, followed by 1N NaOH (0.366 ml). LCMS analysis showed the complete consumption of the 2,4,6-trichloro-1,3,5-triazine. The crude product was used in the next step. MS (ES+): m/e 283.06 [M+H]+.

1. additionwas added
2. customthe complete consumption of the 2,4,6-trichloro-1,3,5-triazine