Methylamine → HCID 178482384, compound

Participants

Reaction Steps

Cold methylamine (40% (w) in water, 234 μL, 1 equivalent) was added to the crude solution of cis-4-(4,6-dichloro-1,3,5-triazin-2-ylamino)cyclohexanecarboxylic acid (2.7 mmol) in CH3CN/H2O (1/1, 20 ml), followed by 1N NaOH (5.34 ml, 1 equivalent). The reaction mixture was stirred at room temperature for 2-3 hrs. The crude product was used in the next step. MS (ES+): m/e 286.09 [M+H]+.

Provenance & Evidence