Methylamine → HCID 178482384, compound

HRID 1671761Notes

Reaction equation

HRID 1671761 reaction equation
[CH3:1][NH2:2].Cl[C:4]1[N:9]=[C:8]([Cl:10])[N:7]=[C:6]([NH:11][C@@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2)[N:5]=1.[OH-].[Na+]>CC#N.O>[Cl:10][C:8]1[N:9]=[C:4]([NH:2][CH3:1])[N:5]=[C:6]([NH:11][C@@H:12]2[CH2:17][CH2:16][C@H:15]([C:18]([OH:20])=[O:19])[CH2:14][CH2:13]2)[N:7]=1

Participants

5

Reactant 3

HCID 6329MethylamineHCID 14798Sodium HydroxideHCID 178525764HCID 178525764, compound

Product 1

HCID 178482384HCID 178482384, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

Cold methylamine (40% (w) in water, 234 μL, 1 equivalent) was added to the crude solution of cis-4-(4,6-dichloro-1,3,5-triazin-2-ylamino)cyclohexanecarboxylic acid (2.7 mmol) in CH3CN/H2O (1/1, 20 ml), followed by 1N NaOH (5.34 ml, 1 equivalent). The reaction mixture was stirred at room temperature for 2-3 hrs. The crude product was used in the next step. MS (ES+): m/e 286.09 [M+H]+.

Sources & evidence

ORD record
ord-1468d0bad9414c8cbaf02257d992a208
Source dataset
uspto-grants-2011_08
Patent number
US07994317B2

Reaction notes

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