Sodium Hydroxide → HCID 178525765, compound

HRID 1671764Notes

Reaction equation

HRID 1671764 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([N:9]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]=1.[NH2:16][C@@H:17]1[CH2:22][CH2:21][C@H:20]([C:23]([OH:25])=[O:24])[CH2:19][CH2:18]1.[OH-].[Na+]>CC#N.O>[N:9]1([C:4]2[N:5]=[C:6]([Cl:8])[N:7]=[C:2]([NH:16][C@@H:17]3[CH2:22][CH2:21][C@H:20]([C:23]([OH:25])=[O:24])[CH2:19][CH2:18]3)[N:3]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 30624831H-Azepine, 1-(4,6-dichloro-1,3,5-triazin-2-yl)hexahydro- (9CI)HCID 178511566HCID 178511566, compound

Product 1

HCID 178525765HCID 178525765, compound

Reagents, catalysts & solvents 1

HCID 18373917Acetonitrile--water (1/1)Solvent

Procedure

To the solution of crude 1-(4,6-dichloro-1,3,5-triazin-2-yl)azepane (0.77 mmol) in CH3CN/H2O (1/1, 20 ml) was added cis-4-amino-cyclohexanecarboxylic acid (110 mg, 0.77 mmol, 1 equivalent), followed by 1N NaOH (1.54 ml, 1.54 mmol, 2 equivalents). The reaction mixture was stirred at room temperature 5-6 hrs. The crude product was used in the next step.

Sources & evidence

ORD record
ord-cd033114dc1c4bcea43f5894e3cf4463
Source dataset
uspto-grants-2011_08
Patent number
US07994317B2

Reaction notes

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