HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 178525765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1H-Azepine, 1-(4,6-dichloro-1,3,5-triazin-2-yl)hexahydro- (9CI) | HCID 3062483 | — |
| Reactant | HCID 178511566 | HCID 178511566 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | HCID 178525765 | HCID 178525765 | — |
Reaction Steps
To the solution of crude 1-(4,6-dichloro-1,3,5-triazin-2-yl)azepane (0.77 mmol) in CH3CN/H2O (1/1, 20 ml) was added cis-4-amino-cyclohexanecarboxylic acid (110 mg, 0.77 mmol, 1 equivalent), followed by 1N NaOH (1.54 ml, 1.54 mmol, 2 equivalents). The reaction mixture was stirred at room temperature 5-6 hrs. The crude product was used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07994317B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cd033114dc1c4bcea43f5894e3cf4463 |
| Source note | uspto-grants-2011_08 |