HCID 57527233, compound → HCID 57527244, compound

HRID 1671798Notes

Reaction equation

HRID 1671798 reaction equation
[CH:1]([NH:4][C:5]1[S:6][C:7]2[C:8]([N:15]=1)=[N:9][CH:10]=[C:11]([CH2:13][OH:14])[CH:12]=2)([CH3:3])[CH3:2]>C1COCC1.[O-2].[Mn+4].[O-2]>[CH:1]([NH:4][C:5]1[S:6][C:7]2[C:8]([N:15]=1)=[N:9][CH:10]=[C:11]([CH:13]=[O:14])[CH:12]=2)([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 57527233HCID 57527233, compound

Product 1

HCID 57527244HCID 57527244, compoundYield 50%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of the above-obtained (2-(isopropylamino)thiazolo[4,5-b]pyridin-6-yl)methanol (≦1.05 mmol) and manganese(IV) oxide (activated, 85%, 1.25 g, 12.2 mmol) in THF (12 mL) was stirred at rt for 3.5 hr. The insoluble material was removed by suction filtration through Celite® 545. The filtrate was concentrated under vacuum and dried over Drierite® under vacuum to give the title compound (0.115 g, 50% yield over two steps) as a pale solid.

Workup

  1. customThe insoluble material was removed by suction filtration through Celite® 545
  2. concentrationThe filtrate was concentrated under vacuum
  3. dry with materialdried over Drierite® under vacuum

Sources & evidence

ORD record
ord-fd98c404ff4a4e78a6429d5d737026b0
Source dataset
uspto-grants-2011_08
Patent number
US07994337B2

Reaction notes

Loading…