Hydrochloric Acid → HCID 178483790, compound

Participants

Reaction Steps

Methyl trans-4-{[[2-(dimethylamino)ethyl] (methyl)amino]-carbonyl}cyclohexanecarboxylate (6.32 g) obtained in Reference Example 83(1) is dissolved in methanol (20 ml), and thereto is added 1 N aqueous sodium hydroxide solution (25 ml). The mixture is stirred at room temperature for 3 hours. To the reaction solution is added 1 N hydrochloric acid (25 ml) and the reaction solution is concentrated under reduced pressure. The residue is lyophilized to give the crude title compound which contains equimolar sodium chloride (6.71 g). APCI-MS M/Z: 257[M+H]+.

Provenance & Evidence