Hydrochloric Acid → HCID 178483790, compound

HRID 16718Notes

Reaction equation

HRID 16718 reaction equation
[CH3:1][N:2]([CH3:19])[CH2:3][CH2:4][N:5]([CH3:18])[C:6]([C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]([O:16]C)=[O:15])[CH2:10][CH2:9]1)=[O:7].[OH-].[Na+].Cl>CO>[CH3:1][N:2]([CH3:19])[CH2:3][CH2:4][N:5]([CH3:18])[C:6]([C@H:8]1[CH2:13][CH2:12][C@H:11]([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178501159HCID 178501159, compound

Product 1

HCID 178483790HCID 178483790, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl trans-4-{[[2-(dimethylamino)ethyl] (methyl)amino]-carbonyl}cyclohexanecarboxylate (6.32 g) obtained in Reference Example 83(1) is dissolved in methanol (20 ml), and thereto is added 1 N aqueous sodium hydroxide solution (25 ml). The mixture is stirred at room temperature for 3 hours. To the reaction solution is added 1 N hydrochloric acid (25 ml) and the reaction solution is concentrated under reduced pressure. The residue is lyophilized to give the crude title compound which contains equimolar sodium chloride (6.71 g). APCI-MS M/Z: 257[M+H]+.

Workup

  1. concentrationthe reaction solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-6471e50f4cdc4537be664d86f2c44c28
Source dataset
uspto-grants-2010_06
Patent number
US07737161B2

Reaction notes

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