Hexane → HCID 67334150, compound

HRID 1671835Notes

Reaction equation

HRID 1671835 reaction equation
CCCCCC.C([Li])CCC.Br[C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:24]=[C:23]([C:25]3[CH:30]=[CH:29][C:28]([C:31]([CH3:34])([CH3:33])[CH3:32])=[CH:27][CH:26]=3)[N:22]=[C:21]([C:35]3[CH:40]=[CH:39][C:38]([C:41]([CH3:44])([CH3:43])[CH3:42])=[CH:37][CH:36]=3)[N:20]=2)=[CH:15][CH:14]=1.Br[C:46]1[CH:51]=[CH:50][C:49]([C:52]2[CH:57]=[CH:56][C:55]([C:58]3[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=3)=[CH:54][N:53]=2)=[CH:48][CH:47]=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O1CCCC1>[C:31]([C:28]1[CH:29]=[CH:30][C:25]([C:23]2[N:22]=[C:21]([C:35]3[CH:36]=[CH:37][C:38]([C:41]([CH3:42])([CH3:44])[CH3:43])=[CH:39][CH:40]=3)[N:20]=[C:19]([C:16]3[CH:15]=[CH:14][C:13]([C:46]4[CH:47]=[CH:48][C:49]([C:52]5[CH:57]=[CH:56][C:55]([C:58]6[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=6)=[CH:54][N:53]=5)=[CH:50][CH:51]=4)=[CH:18][CH:17]=3)[N:24]=2)=[CH:26][CH:27]=1)([CH3:34])([CH3:32])[CH3:33]

Participants

7

Reactant 4

HCID 8058HexaneHCID 23181551HCID 23181551, compoundHCID 594397872-(4-Bromophenyl)-4,6-bis(4-tert-butylphenyl)-1,3,5-triazineHCID 178418339Butyllithium

Product 1

HCID 67334150HCID 67334150, compoundYield 43.1%

Reagents, catalysts & solvents 2

HCID 178418397HCID 178418397, compoundCatalystHCID 8028TetrahydrofuranSolvent2×

Conditions

Temperature
-78 °C

Procedure

Under a stream of argon, 0.35 ml of a hexane solution containing 0.55 mmol of butyl lithium was slowly added to 15 ml of tetrahydrofuran cooled to −78° C. in which 0.25 g of 2-(4-bromophenyl)-4,6-bis(4-tert-butylphenyl)-1,3,5-triazine obtained by Reference Example 1 had been dissolved. After stirring at −78° C. for 15 minutes, 0.15 g of dichloro(tetramethylethylenediamine)zinc(II) was added thereto and stirred at −78° C. for 10 minutes and then at room temperature for 2 hours. A 5 ml portion of tetrahydrofuran prepared by dissolving 0.19 g of 2-(4-bromophenyl)-5-phenylpyridine and 0.03 g of tetrakis(triphenylphosphine)palladium(0) therein was added to this solution and stirred under heating reflux for 14 hours. The reaction solution was concentrated under a reduced pressure and the thus obtained solid was recrystallized from dichloromethane-methanol. The thus obtained crude product was purified by a silica gel column chromatography (eluting solution hexane:chloroform=1:1 to 4:5) and then again recrystallized from dichloromethane-methanol to obtain a white solid of the intended 2,4-bis(4-tert-butylphenyl)-6-[4′-(5-phenylpyridin-2-yl)biphenyl-4-yl]-1,3,5-triazin (0.14 g, yield 43%). Its melting point is shown in Table 4. In this case, a distinct point of glass transition was not observed.

Workup

  1. customobtained by Reference Example 1
  2. dissolutionhad been dissolved
  3. stirringstirred at −78° C. for 10 minutes
  4. waitat room temperature for 2 hours
  5. additiontherein was added to this solution
  6. stirringstirred
  7. temperatureunder heating
  8. temperaturereflux for 14 hours
  9. concentrationThe reaction solution was concentrated under a reduced pressure
  10. customthe thus obtained solid was recrystallized from dichloromethane-methanol
  11. customThe thus obtained crude product
  12. customwas purified by a silica gel column chromatography (eluting solution hexane:chloroform=1:1 to 4:5)
  13. customagain recrystallized from dichloromethane-methanol

Sources & evidence

ORD record
ord-0b7c883be9864fd6999c0f629f791389
Source dataset
uspto-grants-2011_08
Patent number
US07994316B2

Reaction notes

Loading…