反应详情

温度

-78 °C

Under a stream of argon, 2.2 ml of a hexane solution containing 3.3 mmol of butyl lithium was slowly added to 60 ml of tetrahydrofuran cooled to −78° C. in which 1.62 g of 2,4-bis(4-biphenylyl)-6-(4-bromophenyl)-1,3,5-triazine obtained in Reference Example 3 had been dissolved. After stirring at −78° C. for 15 minutes, 0.91 g of dichloro(tetramethylethylenediamine)zinc(II) was added thereto and stirred at −78° C. for 10 minutes and then at room temperature for 2 hours. A 30 ml portion of tetrahydrofuran prepared by dissolving 0.71 g of 5-bromo-2,4′-bipyridyl and 0.14 g of tetrakis(triphenylphosphine)palladium(0) therein was added to this solution and stirred under heating reflux for 14 hours. The reaction solution was concentrated under a reduced pressure and the thus obtained solid was recrystallized from dichloromethane-methanol. The thus obtained crude product was purified by a silica gel column chromatography (eluting solution hexane:chloroform=2:1 to chloroform) and an alumina gel column chromatography (eluting solution hexane:chloroform=1:1) and then recrystallized from dichloromethane-methanol to obtain a white solid of the intended 5-{4-[4,6-bis(4-biphenylyl)-1,3,5-triazin-2-yl]phenyl}-2,4′-bipyridyl (1.00 g, yield 54%).

1. customobtained in Reference Example 3
2. dissolutionhad been dissolved
3. stirringstirred at −78° C. for 10 minutes
4. waitat room temperature for 2 hours
5. additiontherein was added to this solution
6. stirringstirred
7. temperatureunder heating
8. temperaturereflux for 14 hours
9. concentrationThe reaction solution was concentrated under a reduced pressure
10. customthe thus obtained solid was recrystallized from dichloromethane-methanol
11. customThe thus obtained crude product
12. customwas purified by a silica gel column chromatography (eluting solution hexane:chloroform=2:1 to chloroform)
13. washan alumina gel column chromatography (eluting solution hexane:chloroform=1:1)
14. customrecrystallized from dichloromethane-methanol