HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Methyl (2s)-3-amino-2-[({2,6-dimethyl-4-[3-(n-{2-[(phenylmethoxy)carbonylamino]ethyl}carbamoyl)propoxy]phenyl}sulfonyl)amino]propanoate trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | DPC-AG1166-00 (L-Isomer) | HCID 59033702 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl (2s)-3-amino-2-[({2,6-dimethyl-4-[3-(n-{2-[(phenylmethoxy)carbonylamino]ethyl}carbamoyl)propoxy]phenyl}sulfonyl)amino]propanoate trifluoroacetate | HCID 67343702 | — |
Reaction Steps
Compound 22 was dissolved in CH2Cl2:Trifluoroacetic acid and stirred at room temperature for 30 min under nitrogen, after which it was concentrated, evaporated 6×CH2Cl2, and dried under high vacuum to afford 23 (pale yellow oil, 3.14 g). This was used as is in Step 17.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998462B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-a12f586b50fa4edba95b1c6ea47d82ac |
| Source note | uspto-grants-2011_08 |