HRID1672097

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：COC(=O)[C@H](CNC(=O)OC(C)(C)C)NS(=O)(=O)c1c(C)cc(OCCCC(=O)NCCNC(=O)OCc2ccccc2)cc1C

HCID59033702

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CN)NS(=O)(=O)c1c(C)cc(OCCCC(=O)NCCNC(=O)OCc2ccccc2)cc1C.O=C(O)C(F)(F)F

HCID67343702

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

Compound 22 was dissolved in CH2Cl2:Trifluoroacetic acid and stirred at room temperature for 30 min under nitrogen, after which it was concentrated, evaporated 6×CH2Cl2, and dried under high vacuum to afford 23 (pale yellow oil, 3.14 g). This was used as is in Step 17.

WORKUP

后处理

concentrationafter which it was concentrated
customevaporated 6×CH2Cl2
customdried under high vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a12f586b50fa4edba95b1c6ea47d82ac
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07998462B2
来源说明: uspto-grants-2011_08

反应 SMILES

C(OC([NH:8][CH2:9][C@H:10]([NH:15][S:16]([C:19]1[C:24]([CH3:25])=[CH:23][C:22]([O:26][CH2:27][CH2:28][CH2:29][C:30](=[O:45])[NH:31][CH2:32][CH2:33][NH:34][C:35]([O:37][CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[O:36])=[CH:21][C:20]=1[CH3:46])(=[O:18])=[O:17])[C:11]([O:13][CH3:14])=[O:12])=O)(C)(C)C.[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>C(Cl)Cl>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[NH2:8][CH2:9][C@H:10]([NH:15][S:16]([C:19]1[C:24]([CH3:25])=[CH:23][C:22]([O:26][CH2:27][CH2:28][CH2:29][C:30](=[O:45])[NH:31][CH2:32][CH2:33][NH:34][C:35]([O:37][CH2:38][C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)=[O:36])=[CH:21][C:20]=1[CH3:46])(=[O:17])=[O:18])[C:11]([O:13][CH3:14])=[O:12]