Hydrochloric Acid → HCID 24988151, compound

HRID 1672099Notes

Reaction equation

HRID 1672099 reaction equation
C(O[C:6]([N:8](C)[O:9][C:10](=[O:16])[CH2:11][CH2:12][C:13]([OH:15])=[O:14])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:6][NH:8][O:9][C:10](=[O:16])[CH2:11][CH2:12][C:13]([OH:15])=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86628342HCID 86628342, compound

Product 1

HCID 24988151HCID 24988151, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 4-(tert-butoxycarbonyl(methyl)aminooxy)-4-oxobutanoic acid (96 mg, 0.389) in dioxane (3 mL) was added 4 M HCl solution in dioxane (2 mL). The reaction mixture was stirred at room temperature for 20 h and concentrated. The desired product was obtained as a white solid (72 mg, 0.389 mmol, 100%). 1H NMR (CD3OD, 400 MHz): δ (ppm) 2.53-2.57 (m, 2H), 2.68-2.77 (m, 2H), 2.94 (s, 3H).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-7ee8268a57c14e58864e83305dbf40fa
Source dataset
uspto-grants-2011_08
Patent number
US07998486B2

Reaction notes

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