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HRID1672127

反应详情

EQUATION

反应方程式

HRID 1672127 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)Cl
HCID31297

Methanesulfonyl chloride

CH3ClO2S

结构：CN1CCN([C@H]2CC[C@@H](O)CC2)CC1=O
HCID178481020

未命名化合物

PRODUCTS

生成物

1
结构：CN1CCN([C@H]2CC[C@@H](OS(C)(=O)=O)CC2)CC1=O
HCID178481022

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

0.24 ml methanesulphonic acid chloride are added dropwise at 0° C. to 500 mg (cis)-1-hydroxy-4-(4-methyl-3-oxo-piperazin-1-yl)-cyclohexane and 0.52 ml N,N-isopropyl-ethylamine in 10 ml dichloromethane and stirred for 1.5 hours at ambient temperature. The product is purified by column chromatography.

WORKUP

后处理

  1. customThe product is purified by column chromatography