Methanesulfonyl chloride → HCID 178481022, compound

HRID 1672127Notes

Reaction equation

HRID 1672127 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][C@H:7]1[CH2:12][CH2:11][C@@H:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[C:15](=[O:20])[CH2:14]2)[CH2:9][CH2:8]1>ClCCl>[CH3:1][S:2]([O:6][C@H:7]1[CH2:8][CH2:9][C@@H:10]([N:13]2[CH2:18][CH2:17][N:16]([CH3:19])[C:15](=[O:20])[CH2:14]2)[CH2:11][CH2:12]1)(=[O:4])=[O:3]

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 178481020HCID 178481020, compound

Product 1

HCID 178481022HCID 178481022, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.24 ml methanesulphonic acid chloride are added dropwise at 0° C. to 500 mg (cis)-1-hydroxy-4-(4-methyl-3-oxo-piperazin-1-yl)-cyclohexane and 0.52 ml N,N-isopropyl-ethylamine in 10 ml dichloromethane and stirred for 1.5 hours at ambient temperature. The product is purified by column chromatography.

Workup

  1. customThe product is purified by column chromatography

Sources & evidence

ORD record
ord-c31c02065f9343ab9eb82cc2d780cfde
Source dataset
uspto-grants-2011_08
Patent number
US07998949B2

Reaction notes

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