反应详情

17 ml of a 1M L-Selctride solution (in tetrahydrofuran) are added dropwise at −78° C. to 3.3 g 4-(4-methyl-3-oxo-piperazin-1-yl)-cyclohexan-1-one in 100 ml abs. tetrahydrofuran. After 5.5 hours 20 ml of methanol are added and the solution is evaporated down. The residue is purified by column chromatography. The mixture of cis- and trans-compound is separated by preparative HPLC.

1. customthe solution is evaporated down
2. customThe residue is purified by column chromatography
3. additionThe mixture of cis- and trans-compound
4. customis separated by preparative HPLC