Sodium Hydroxide → HCID 59158172, compound

HRID 1672130Notes

Reaction equation

HRID 1672130 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:17][CH2:16][C:11]3(OCC[O:12]3)[CH2:10][CH2:9]2)[CH2:4][C:3]1=[O:18].[OH-].[Na+]>Cl>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]2[CH2:9][CH2:10][C:11](=[O:12])[CH2:16][CH2:17]2)[CH2:4][C:3]1=[O:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 591581918-(4-Methyl-3-oxo-piperazin-1-yl)-1,4-dioxa-spiro[4,5]decane

Product 1

HCID 59158172HCID 59158172, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2.3 g 8-(4-methyl-3-oxo-piperazin-1-yl)-1,4-dioxa-spiro[4,5]decane are stirred in 20 ml of 4M HCl for 48 hours at ambient temperature, for 7 hours at 50° C. and for two hours at 70° C. The mixture is made alkaline with 4M sodium hydroxide solution and extracted five times with 40 ml dichloromethane. The organic phase is evaporated down and the product is purified by column chromatography.

Workup

  1. extractionextracted five times with 40 ml dichloromethane
  2. customThe organic phase is evaporated down
  3. customthe product is purified by column chromatography

Sources & evidence

ORD record
ord-462a7b997b654de9a296532bd71aea27
Source dataset
uspto-grants-2011_08
Patent number
US07998949B2

Reaction notes

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