Water → HCID 178481021, compound

Participants

Reaction Steps

10.0 g (trans)-1-hydroxy-4-{[N-(2,2-dimethoxy-ethyl)-N-methyl-amino]-carbonylmethylamino}-cyclohexane are hydrogenated in a solution of 60 ml of water, 140 ml of methanol and 10.5 g methanesulphonic acid with 3.25 g platinum on charcoal (5% Pt) for 24 hours at 50° C. The solution is made alkaline with 50% sodium hydroxide solution and evaporated down. The residue is extracted with dichloromethane. The organic phase is dried on magnesium sulphate and evaporated down.

Provenance & Evidence