反应详情

10.0 g (trans)-1-hydroxy-4-{[N-(2,2-dimethoxy-ethyl)-N-methyl-amino]-carbonylmethylamino}-cyclohexane are hydrogenated in a solution of 60 ml of water, 140 ml of methanol and 10.5 g methanesulphonic acid with 3.25 g platinum on charcoal (5% Pt) for 24 hours at 50° C. The solution is made alkaline with 50% sodium hydroxide solution and evaporated down. The residue is extracted with dichloromethane. The organic phase is dried on magnesium sulphate and evaporated down.

1. customevaporated down
2. extractionThe residue is extracted with dichloromethane
3. customThe organic phase is dried on magnesium sulphate
4. customevaporated down