HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 178486859, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol | HCID 57476868 | — |
| Reactant | HCID 178481022 | HCID 178481022 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 178486859 | HCID 178486859 | — |
Reaction Steps
Prepared by reacting 4-[(3-chloro-2-fluoro-phenyl)amino]-6-hydroxy-7-methoxy-quinazoline with (cis)-1-methanesulphonyloxy-4-(4-methyl-3-oxo-piperazin-1-yl)-cyclohexane in N-methyl-2-pyrrolidinone at 125° C. in the presence of potassium carbonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998949B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-96e4c5944af646d4802894f06aee7e62 |
| Source note | uspto-grants-2011_08 |