Potassium Carbonate → HCID 178486859, compound

HRID 1672135Notes

Reaction equation

HRID 1672135 reaction equation
[Cl:1][C:2]1[C:3]([F:22])=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:20][CH3:21])=[C:16]([OH:19])[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.CS(O[C@H:28]1[CH2:33][CH2:32][C@@H:31]([N:34]2[CH2:39][CH2:38][N:37]([CH3:40])[C:36](=[O:41])[CH2:35]2)[CH2:30][CH2:29]1)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CN1CCCC1=O>[Cl:1][C:2]1[C:3]([F:22])=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([O:20][CH3:21])=[C:16]([O:19][C@H:28]4[CH2:29][CH2:30][C@H:31]([N:34]5[CH2:39][CH2:38][N:37]([CH3:40])[C:36](=[O:41])[CH2:35]5)[CH2:32][CH2:33]4)[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 574768684-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-olHCID 178481022HCID 178481022, compound

Product 1

HCID 178486859HCID 178486859, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Prepared by reacting 4-[(3-chloro-2-fluoro-phenyl)amino]-6-hydroxy-7-methoxy-quinazoline with (cis)-1-methanesulphonyloxy-4-(4-methyl-3-oxo-piperazin-1-yl)-cyclohexane in N-methyl-2-pyrrolidinone at 125° C. in the presence of potassium carbonate.

Workup

  1. customPrepared
  2. customat 125° C.

Sources & evidence

ORD record
ord-96e4c5944af646d4802894f06aee7e62
Source dataset
uspto-grants-2011_08
Patent number
US07998949B2

Reaction notes

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