Potassium Acetate → HCID 178526770, compound

HRID 1672312Notes

Reaction equation

HRID 1672312 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]=[CH:12][CH2:13][N+:14]([O-:16])=[O:15])=[C:6]([CH:10]=1)[C:7](O)=[O:8].C([O-])(=O)C.[K+]>C(OC(=O)C)(=O)C>[F:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[N:11]=[CH:12][C:13]([N+:14]([O-:16])=[O:15])=[C:7]2[OH:8]

Participants

4

Reactant 2

HCID 517044Potassium AcetateHCID 60046931HCID 60046931, compound

Product 1

HCID 178526770HCID 178526770, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

4 g (17.6 mmol) of 5-fluoro-2-[2-nitro-ethylideneamino]-benzoic acid (Example 19a) in 35 ml acetic anhydride are heated (ca. 100° C.) until a clear solution is obtained. 2 g (21.2 mmol) of potassium acetate are added and stirring is continued for 30 min (tlc-control). The reaction mixture is cooled to rt and the formed crystals are filtered off and washed several times with acetic acid and water. mp: 313° C.; MS: 207 (M+−1); HPLC: tret=9.94 min (Grad 3).

Workup

  1. customis obtained
  2. filtrationthe formed crystals are filtered off
  3. washwashed several times with acetic acid and water
  4. customtret=9.94 min (Grad 3)

Sources & evidence

ORD record
ord-949388d34141422aa13a827ce24a5a8f
Source dataset
uspto-grants-2011_08
Patent number
US07998972B2

Reaction notes

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