HCID 9996042, compound → HCID 11723681, compound

HRID 1672319Notes

Reaction equation

HRID 1672319 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]=[CH:13][N:14]([C:15]4[CH:20]=[CH:19][C:18]([CH2:21][C:22]#[N:23])=[CH:17][CH:16]=4)[C:5]=3[C:4]=2[CH:3]=1>CO.N=[N+]=[N-].[Ni]>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]=[CH:13][N:14]([C:15]4[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][NH2:23])=[CH:17][CH:16]=4)[C:5]=3[C:4]=2[CH:3]=1

Participants

4

Reactant 1

HCID 9996042HCID 9996042, compound

Product 1

HCID 11723681HCID 11723681, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 131729106HCID 131729106, compoundSolvent

Procedure

In analogy to Example 42, the title compound is prepared from 400 mg (1.25 mmol) [4-(8-chloro-imidazo[4,5-c]quinolin-1-yl)phenyl]-acetonitrile (Example 39) in 65 ml methanol/HN3 aqu. 10% and 250 mg Raney-Ni. mp: 140-141° C.; MS: 323 (M++1); HPLC: tret=8.98 min (Grad 3).

Workup

  1. customtret=8.98 min (Grad 3)

Sources & evidence

ORD record
ord-854ab82e4f224e3db3e5440a6007eac1
Source dataset
uspto-grants-2011_08
Patent number
US07998972B2

Reaction notes

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