Phosphorus oxychloride → HCID 60046942, compound

HRID 1672331Notes

Reaction equation

HRID 1672331 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([N+:13]([O-:15])=[O:14])=[C:6]2O)[CH3:2].O=P(Cl)(Cl)[Cl:19]>>[Cl:19][C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([CH2:1][CH3:2])[CH:4]=2)[N:9]=[CH:8][C:7]=1[N+:13]([O-:15])=[O:14]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178435581HCID 178435581, compound

Product 1

HCID 60046942HCID 60046942, compound

Procedure

The title compound is prepared in analogy to Example 19c starting from 3.6 g (16.49 mmol) 6-ethyl-3-nitro-quinolin-4-ol (Example 49d) and 24 ml POCl3. mp: 290-295° C.; MS: 237 (M++1); HPLC: tret=13.72 min (Grad 1).

Workup

  1. customtret=13.72 min (Grad 1)

Sources & evidence

ORD record
ord-345a2ee7485d4ed2a0b5d8a1da43cc6d
Source dataset
uspto-grants-2011_08
Patent number
US07998972B2

Reaction notes

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