Phosphorus oxychloride → HCID 60046927, compound

HRID 1672335Notes

Reaction equation

HRID 1672335 reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][C:7]2[C:12]([C:13]=1O)=[CH:11][C:10]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:9][CH:8]=2)([O-:3])=[O:2].O=P(Cl)(Cl)[Cl:23]>>[Cl:23][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:11]=2)[N:6]=[CH:5][C:4]=1[N+:1]([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178526760HCID 178526760, compound

Product 1

HCID 60046927HCID 60046927, compound

Procedure

The title compound is prepared in analogy to Example 19e, starting from 900 mg (3.38 mmol) 3-nitro-6-phenyl-quinolin-4-ol (Example 53c) in 10 ml POCl3. The compound is crystallized from ethylacetate-hexane. mp: 144-145° C.; MS: 284 (M++1); HPLC: tret=140.51 min (Grad 1).

Workup

  1. customThe compound is crystallized from ethylacetate-hexane
  2. customtret=140.51 min (Grad 1)

Sources & evidence

ORD record
ord-052e4f0bd3594a9bab9bf14d57e4f4c2
Source dataset
uspto-grants-2011_08
Patent number
US07998972B2

Reaction notes

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