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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1672379Generated: October 31, 2026

Diisopropylethylamine → 7-(2-Chlorophenyl)-1-{[4-(difluoromethoxy)phenyl]sulfonyl}-1,7-diazaspiro[4.4]-nonan-6-one

https://huagongshe.com/reaction/1672379

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiisopropylethylamineHCID 81531—
Reactant4-(Difluoromethoxy)benzenesulfonyl chlorideHCID 2778223—
Reactant7-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-oneHCID 58948331—
SolventDichloromethaneHCID 6344—
Product7-(2-Chlorophenyl)-1-{[4-(difluoromethoxy)phenyl]sulfonyl}-1,7-diazaspiro[4.4]-nonan-6-oneHCID 67354943—

Reaction Steps

7-(2-Chlorophenyl)-1,7-diazaspiro[4.4]nonan-6-one (20 mg, 0.00008 mol) was dissolved in DCM. To this solution was added N,N-diisopropylethylamine (DIPEA) (42 μL, 0.00024 mol) and 4-(difluoromethoxy)benzenesulfonyl chloride (21 mg, 0.000088 mol) at 0° C. The solution was allowed to gradually warm to RT while stirring for 18 h. LC-MS: 457.1 (M+1H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07998959B2
Source datasetuspto-grants-2011_08
ORD IDord-6cadd035022442a6a50c3e2f6bb02bce
Source noteuspto-grants-2011_08