反应详情

温度

0 °C

1,1-Bis(hydroxymethyl)cyclopropane (1.0 g, 0.0098 mol), triethylamine (TEA) (2.0 mL, 0.015 mol), and 1H-imidazole (0.13 g, 0.0020 mol) were dissolved in anhydrous DCM (15 mL) and the solution was cooled to 0° C. A solution of tert-butyldimethylsilyl chloride (1.55 g, 0.0103 mol) in DCM (5 mL) was added drop-wise and the resulting mixture was allowed to warm to RT and stirred overnight. The reaction was quenched with saturated aqueous NaHCO3 and extracted with DCM (3×). The organic extract was dried (magnesium sulfate), filtered, and concentrated in vacuo. The crude product was identified by 1H NMR and used in the next step without further purification.

1. temperatureto warm to RT
2. customThe reaction was quenched with saturated aqueous NaHCO3
3. extractionextracted with DCM (3×)
4. extractionThe organic extract
5. dry with materialwas dried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customused in the next step without further purification