HCID 24759086, compound → HCID 67355797, compound

HRID 1672387Notes

Reaction equation

HRID 1672387 reaction equation
C([N:8]1[CH:14]([C:15]([NH:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[O:16])[CH2:13][C:10]2([CH2:12][CH2:11]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH:18]1([NH:17][C:15]([CH:14]2[CH2:13][C:10]3([CH2:11][CH2:12]3)[CH2:9][NH:8]2)=[O:16])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 24759086HCID 24759086, compound

Product 1

HCID 67355797HCID 67355797, compoundYield 103.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5-Benzyl-N-cyclohexyl-5-azaspiro[2.4]heptane-6-carboxamide (prepared according to Example 30, 14 mg, 0.0000448 mol) was dissolved in methanol (1 mL). To this solution was added Pd/C (3 mg) and the resulting mixture was stirred under an atmosphere of hydrogen overnight. The catalyst was filtered off and the volatiles were removed in vacuo to afford the desired product (10.3 mg), which was used in the next step without further purification. LC/MS: 223.2 (M+H)+.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-47c89cab1ac7435fad40d2fac8ffb8b6
Source dataset
uspto-grants-2011_08
Patent number
US07998959B2

Reaction notes

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