Sodium ethanethiolate → HCID 178515881, compound

HRID 1672446Notes

Reaction equation

C[O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[N:11]=[C:10]([NH:13][C@H:14]1[CH2:19][CH2:18][C@H:17]([OH:20])[CH2:16][CH2:15]1)[N:9]=[CH:8]2.C([S-])C.[Na+]>CN(C=O)C>[OH:20][C@H:17]1[CH2:16][CH2:15][C@H:14]([NH:13][C:10]2[N:9]=[CH:8][C:7]3[C:12](=[C:3]([OH:2])[CH:4]=[CH:5][CH:6]=3)[N:11]=2)[CH2:19][CH2:18]1

Participants

Conditions

Temperature: 11 °C

Procedure

To a solution of trans-4-[(8-methoxyquinazolin-2-yl)amino]cyclohexanol (5.90 g, 21.6 mmol) in DMF (300 mL) was added sodium ethanethiolate (5.45 g, 65 mmol) and the mix heated to 11° C. for 3 hours under nitrogen. The reaction was cooled to ambient temperature and the DMF removed in-vacuo. The residue was diluted with MeOH (20 mL), DCM (200 mL) and EtOAc (100 mL) and then acidified with 1 M HCl to pH=1. The mix was concentrated in-vacuo where a yellow ppt crashed out. This was filtered off, washed with water (2×50 mL), EtOAc (100 mL) and dried to yield the title compound as a yellow solid, 4.9 g, 88%. 1H NMR (400 MHz, DMSO-D6) δ ppm 9.00 (2H, s) 7.21 (1H, d, J=6.32 Hz) 7.16 (1H, s) 6.98-7.09 (2H, m) 4.55 (1H, s) 3.36 (2H, d, J=23.75 Hz) 1.86 (4H, dd, J=28.30, 8.59 Hz) 1.22-1.48 (4H, m); MS (API+) for C14H17N3O2 m/z 260.2 (M+H)+.

Workup

temperatureThe reaction was cooled to ambient temperature
customthe DMF removed in-vacuo
additionThe residue was diluted with MeOH (20 mL), DCM (200 mL) and EtOAc (100 mL)
concentrationThe mix was concentrated in-vacuo where a yellow ppt
filtrationThis was filtered off
washwashed with water (2×50 mL), EtOAc (100 mL)
customdried

Sources & evidence

ORD record: ord-090e7585879a4fe3862f3cbc8f5793dd
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07998978B2

Reaction notes

Loading…