反应详情

温度

155 °C

A mixture of methyl 2-amino-3-methoxy-4-methylbenzoate (139.3 g, 0.714 mol) and urea (214.3 g, 3.57 mol) was heated in an oil bath at 110˜120° C. for 30 minutes. The temperature was then raised to 150-160° C. and the reaction mixture was stirred at this temperature for 8 h. TLC (petroleum ether/ethyl acetate=3:1) indicated the reaction was complete. The mixture was washed with EtOH (1.5 L) and water (1 L×6) and dried in vacuo to give the title compound (123 g, 83.7%) as a light brown solid.

1. temperaturewas heated in an oil bath at 110˜120° C. for 30 minutes
2. washThe mixture was washed with EtOH (1.5 L) and water (1 L×6)
3. customdried in vacuo