HRID1672501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2761083

1-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzene

C8H8BrClO2S

HCID18629015

未命名化合物

HCID21569048

未命名化合物

结构：Cc1cc(C#N)cc(Cl)c1Oc1nc(NC2CCNCC2)ncc1Br

HCID67340085

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C#N)cc(C)c1Oc1nc(NC2CCN(Cc3ccc(S(C)(=O)=O)cc3)CC2)ncc1Br

HCID49798183

未命名化合物

PROCEDURE

实验过程

I-51, I-59 and I-60 were prepared analogously except 56 was replaced with 4-[5-bromo-2-(piperidin-4-ylamino)-pyrimidin-4-yloxy]-3-chloro-5-methyl-benzonitrile and 59 was replaced with 1-bromomethyl-2-chloro-4-methanesulfonyl-benzene, 4-bromomethyl-3-chloro-benzamide and 4-bromomethyl-3-chloro-benzenesulfonamide respectively.

WORKUP

后处理

customI-51, I-59 and I-60 were prepared analogously except 56

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fed9c4f67e35405fa9a8509e0069fcab
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07998969B2
来源说明: uspto-grants-2011_08

反应 SMILES

[Br:1][C:2]1[C:3]([O:15][C:16]2[C:23]([CH3:24])=[CH:22][C:19]([C:20]#[N:21])=[CH:18][C:17]=2Cl)=[N:4][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1.Br[CH2:27][C:28]1[CH:33]=[CH:32][C:31]([S:34]([CH3:37])(=[O:36])=[O:35])=[CH:30][C:29]=1Cl.Br[CH2:40]C1C=CC(C(N)=O)=CC=1Cl.BrCC1C=CC(S(N)(=O)=O)=CC=1Cl>>[Br:1][C:2]1[C:3]([O:15][C:16]2[C:23]([CH3:24])=[CH:22][C:19]([C:20]#[N:21])=[CH:18][C:17]=2[CH3:40])=[N:4][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:27][C:28]3[CH:33]=[CH:32][C:31]([S:34]([CH3:37])(=[O:36])=[O:35])=[CH:30][CH:29]=3)[CH2:11][CH2:10]2)=[N:6][CH:7]=1