HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzene → 4-[5-Bromo-2-[[1-[(4-methylsulfonylphenyl)methyl]-4-piperidyl]amino]pyrimidin-4-yl]oxy-3,5-dimethyl-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzene | HCID 2761083 | — |
| Reactant | 4-Bromomethyl-3-chloro-benzenesulfonamide | HCID 18629015 | — |
| Reactant | 4-Bromomethyl-3-chloro-benzamide | HCID 21569048 | — |
| Reactant | 4-[5-Bromo-2-(piperidin-4-ylamino)-pyrimidin-4-yloxy]-3-chloro-5-methyl-benzonitrile | HCID 67340085 | — |
| Product | 4-[5-Bromo-2-[[1-[(4-methylsulfonylphenyl)methyl]-4-piperidyl]amino]pyrimidin-4-yl]oxy-3,5-dimethyl-benzonitrile | HCID 49798183 | — |
Reaction Steps
I-51, I-59 and I-60 were prepared analogously except 56 was replaced with 4-[5-bromo-2-(piperidin-4-ylamino)-pyrimidin-4-yloxy]-3-chloro-5-methyl-benzonitrile and 59 was replaced with 1-bromomethyl-2-chloro-4-methanesulfonyl-benzene, 4-bromomethyl-3-chloro-benzamide and 4-bromomethyl-3-chloro-benzenesulfonamide respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998969B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-fed9c4f67e35405fa9a8509e0069fcab |
| Source note | uspto-grants-2011_08 |