HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1672509Generated: November 1, 2026
1,1'-Carbonyldiimidazole → Imidazole-1-carboxylic acid [5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide
https://huagongshe.com/reaction/1672509
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 5-(3-Fluoro-4-(methylsulfonyl)phenyl)-4-methylthiazol-2-amine | HCID 57351277 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Imidazole-1-carboxylic acid [5-(3-fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-amide | HCID 71480199 | — |
Reaction Steps
A suspension of 5-(3-Fluoro-4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-ylamine (17.5 mmol) and 1,1′-carbonyldiimidazole (4.26 g, 26.3 mmol, 1.5 equivalents) in CH2Cl2 (100 ml) was heated at 40° C.-reflux under argon until no starting material remains (30 min-5 hours) as determined by HPLC and NMR. When cool the solid precipitate was removed by filtration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07998990B2 |
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| Source dataset | uspto-grants-2011_08 |
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| ORD ID | ord-a23ba43ad7e740fdb35c4faebe7f8ea5 |
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| Source note | uspto-grants-2011_08 |
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