HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[2-(2-Fluoro-ethyl)-2H-tetrazol-5-yl]-ethylamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {2-[2-(2-Fluoro-ethyl)-2H-tetrazol-5-yl]-ethyl}-carbamic acid tert-butyl ester | HCID 57466829 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-[2-(2-Fluoro-ethyl)-2H-tetrazol-5-yl]-ethylamine hydrochloride | HCID 67337036 | — |
Reaction Steps
A solution of {2-[2-(2-Fluoro-ethyl)-2H-tetrazol-5-yl]-ethyl}-carbamic acid tert-butyl ester (1.0 g, 3.9 mmol) in dichloromethane (30 ml) was treated with a solution of 4M HCl in dioxane (31 ml) and the reaction mixture stirred for 1 hour. The solvent was evaporated to yield the titled product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998990B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-ace71a3ec12044b3a6a2ec2fe92a4de4 |
| Source note | uspto-grants-2011_08 |