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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1672589Generated: October 27, 2026

3-Fluoro-4-(trifluoromethyl)benzaldehyde → 5-(4-(Trifluoromethyl)phenyl)oxazole

https://huagongshe.com/reaction/1672589

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-(trifluoromethyl)benzaldehydeHCID 2737537—
Reactant1-(1-Isocyanoethanesulfonyl)-4-methylbenzeneHCID 11052885—
Product5-(4-(Trifluoromethyl)phenyl)oxazoleHCID 13268414—

Reaction Steps

The title compound was prepared according to the procedure of Example 1B, substituting 4-(trifluoromethyl)benzaldehyde for 3-fluoro-4-(trifluoromethyl)benzaldehyde and substituting p-toluenesulfonylmethyl isocyanide for 1-(1-isocyanoethylsulfonyl)-4-methylbenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07998993B2
Source datasetuspto-grants-2011_08
ORD IDord-441cf5e56a524babb024196112681b27
Source noteuspto-grants-2011_08