2-(2-Chlorobenzyloxy)-5-fluorobenzyl alcohol → (5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanol

HRID 1672646Notes

Reaction equation

HRID 1672646 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])=[C:6]([CH:11]=1)[C:7](OC)=[O:8].ClC1C=CC=CC=1COC1C=CC(F)=CC=1CO>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:21])([F:22])[F:23])=[C:6]([CH2:7][OH:8])[CH:11]=1

Participants

3

Reactant 2

HCID 578643292-(2-Chlorobenzyloxy)-5-fluorobenzyl alcoholHCID 57864353Methyl 5-fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}benzoate

Product 1

HCID 57864363(5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanolYield 72%

Procedure

The title compound is prepared in 72% yield from methyl 5-fluoro-2-{[2-(trifluoromethyl)benzyl]-oxy}benzoate (Example 47A) in analogy to [2-(2-chlorobenzyloxy)-5-fluorophenyl]methanol (Example 45A).

Sources & evidence

ORD record
ord-372dd0533bf14ac58bf98a6946c548e8
Source dataset
uspto-grants-2011_08
Patent number
US07998988B2

Reaction notes

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