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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1672646Generated: November 1, 2026

2-(2-Chlorobenzyloxy)-5-fluorobenzyl alcohol → (5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanol

https://huagongshe.com/reaction/1672646

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(2-Chlorobenzyloxy)-5-fluorobenzyl alcoholHCID 57864329—
ReactantMethyl 5-fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}benzoateHCID 57864353—
Product(5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanolHCID 5786436372%

Reaction Steps

The title compound is prepared in 72% yield from methyl 5-fluoro-2-{[2-(trifluoromethyl)benzyl]-oxy}benzoate (Example 47A) in analogy to [2-(2-chlorobenzyloxy)-5-fluorophenyl]methanol (Example 45A).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07998988B2
Source datasetuspto-grants-2011_08
ORD IDord-372dd0533bf14ac58bf98a6946c548e8
Source noteuspto-grants-2011_08