(5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanol → 2-(Bromomethyl)-4-fluoro-1-{[2-(trifluoromethyl)benzyl]oxy}benzene

HRID 1672647Notes

Reaction equation

HRID 1672647 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])=[C:6]([CH2:8]O)[CH:7]=1.FC(OC1C=CC(F)=CC=1C[Br:50])(F)C1C=CC(C2C=CC(C(F)(F)F)=CC=2)=CC=1>>[Br:50][CH2:8][C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]([F:21])([F:20])[F:19]

Participants

3

Reactant 2

HCID 57864363(5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanolHCID 578643902-(Bromomethyl)-4-fluorophenyl difluoro[4'-(trifluoromethyl)biphenyl-4-yl]methyl ether

Product 1

HCID 578644252-(Bromomethyl)-4-fluoro-1-{[2-(trifluoromethyl)benzyl]oxy}benzeneYield 80%

Procedure

The title compound is prepared in 80% yield from (5-fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}-phenyl)methanol (Example 48A) in analogy to 2-(bromomethyl)-4-fluorophenyl difluoro[4′-(trifluoromethyl)biphenyl-4-yl]methyl ether (Example 41A).

Sources & evidence

ORD record
ord-465713280fba4ce5b29a162e9e97b942
Source dataset
uspto-grants-2011_08
Patent number
US07998988B2

Reaction notes

Loading…