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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1672647Generated: October 31, 2026

(5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanol → 2-(Bromomethyl)-4-fluoro-1-{[2-(trifluoromethyl)benzyl]oxy}benzene

https://huagongshe.com/reaction/1672647

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}phenyl)methanolHCID 57864363—
Reactant2-(Bromomethyl)-4-fluorophenyl difluoro[4'-(trifluoromethyl)biphenyl-4-yl]methyl etherHCID 57864390—
Product2-(Bromomethyl)-4-fluoro-1-{[2-(trifluoromethyl)benzyl]oxy}benzeneHCID 5786442580%

Reaction Steps

The title compound is prepared in 80% yield from (5-fluoro-2-{[2-(trifluoromethyl)benzyl]oxy}-phenyl)methanol (Example 48A) in analogy to 2-(bromomethyl)-4-fluorophenyl difluoro[4′-(trifluoromethyl)biphenyl-4-yl]methyl ether (Example 41A).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07998988B2
Source datasetuspto-grants-2011_08
ORD IDord-465713280fba4ce5b29a162e9e97b942
Source noteuspto-grants-2011_08