Sodium Hydroxide → HCID 57864424, compound

HRID 1672649Notes

Reaction equation

HRID 1672649 reaction equation
[C:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][O:10][C:11]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:12]=2[C:13]([O:15]C)=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([C:5]1[CH:23]=[CH:22][C:8]([CH2:9][O:10][C:11]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:12]=2[C:13]([OH:15])=[O:14])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57864373HCID 57864373, compound

Product 1

HCID 57864424HCID 57864424, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8.0 g (25 mmol) of methyl 2-(4-tert-butylbenzyloxy)-5-fluorobenzoate are dissolved in 64 ml of methanol and 32 ml of 40% strength sodium hydroxide solution and stirred under reflux for 12 h. The crystals which have separated out are filtered off with suction, washed with water, 1 N hydrochloric acid and petroleum ether and dried on a clay dish. 7.10 g (23.5 mmol, 94% of theory) of the title compound are isolated.

Workup

  1. temperatureunder reflux for 12 h
  2. customThe crystals which have separated out
  3. filtrationare filtered off with suction
  4. washwashed with water, 1 N hydrochloric acid and petroleum ether
  5. customdried on a clay dish

Sources & evidence

ORD record
ord-787fe19ded1144d4b9a4fc849326d960
Source dataset
uspto-grants-2011_08
Patent number
US07998988B2

Reaction notes

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