Sodium Hydroxide → HCID 57864424, compound

Participants

Reaction Steps

8.0 g (25 mmol) of methyl 2-(4-tert-butylbenzyloxy)-5-fluorobenzoate are dissolved in 64 ml of methanol and 32 ml of 40% strength sodium hydroxide solution and stirred under reflux for 12 h. The crystals which have separated out are filtered off with suction, washed with water, 1 N hydrochloric acid and petroleum ether and dried on a clay dish. 7.10 g (23.5 mmol, 94% of theory) of the title compound are isolated.

Provenance & Evidence