Lithium Hydroxide → HCID 57864405, compound

Participants

Reaction Steps

100 mg (0.28 mmol) of methyl 5-fluoro-2-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]benzoate are dissolved in 2 ml of methanol and 2 ml of water, and 20.3 mg (0.85 mmol) of lithium hydroxide are added. After stirring at room temperature for 12 h, the crystals which have separated out are filtered off with suction, washed with water, 1 N hydrochloric acid and petroleum ether and dried on a clay dish. 74.9 mg (0.20 mmol, 71% of theory) of the title compound are isolated.

Provenance & Evidence