Lithium Hydroxide → HCID 57864405, compound

HRID 1672656Notes

Reaction equation

HRID 1672656 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH2:13][C:14]#[C:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)=[C:6]([CH:11]=1)[C:7]([O:9]C)=[O:8].[OH-].[Li+]>CO.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH2:13][C:14]#[C:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:21]=2)=[C:6]([CH:11]=1)[C:7]([OH:9])=[O:8]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 57864358HCID 57864358, compound

Product 1

HCID 57864405HCID 57864405, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

100 mg (0.28 mmol) of methyl 5-fluoro-2-[3-(4-trifluoromethylphenyl)prop-2-ynyloxy]benzoate are dissolved in 2 ml of methanol and 2 ml of water, and 20.3 mg (0.85 mmol) of lithium hydroxide are added. After stirring at room temperature for 12 h, the crystals which have separated out are filtered off with suction, washed with water, 1 N hydrochloric acid and petroleum ether and dried on a clay dish. 74.9 mg (0.20 mmol, 71% of theory) of the title compound are isolated.

Workup

  1. customthe crystals which have separated out
  2. filtrationare filtered off with suction
  3. washwashed with water, 1 N hydrochloric acid and petroleum ether
  4. customdried on a clay dish

Sources & evidence

ORD record
ord-8fd656b0586d435e9e4aa209aac90977
Source dataset
uspto-grants-2011_08
Patent number
US07998988B2

Reaction notes

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