反应详情

Dissolve cis-4-nitro-benzoic acid 4-(2-oxo-pyrrolidin-1-yl)-cyclohexyl ester (87.9 g, 264 mmol) in methanol (1.35 L) and water (150 mL) and treat with potassium carbonate (109.5 g, 800 mmol). Stir at room temperature overnight to give a white precipitate. Evaporate to dryness. Remove excess water by mixing with ethanol and concentrating to dryness under vacuum. Repeat this procedure. Stir in tetrahydrofuran (1 L) for 1 hour then filter. Evaporate the filtrate to an oil and crystallize from diethyl ether (100 mL) to afford 40 g (83%) of the title compound.

1. customto give a white precipitate
2. customEvaporate to dryness
3. additionRemove excess water by mixing with ethanol
4. concentrationconcentrating to dryness under vacuum
5. stirringStir in tetrahydrofuran (1 L) for 1 hour
6. filtrationthen filter
7. customEvaporate the filtrate to an oil
8. customcrystallize from diethyl ether (100 mL)