反应详情

Heat a solution of cis-1-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one (500 mg) in 5 mL of 1N HCl in EtOH to 45° C. for 1 h. Cool the mixture to room temp and concentrate. Dissolve the residue in NaHCO3 (10 mL) and CH2Cl2 (10 mL). Extract the aqueous layer two times with 10 mL of CH2Cl2. Dry the organic layer over Na2SO4, filter and concentrate. Purify the crude material by chromatography to yield the title compound: mass spectrum (m/z): 184 (M+1).

1. concentrationconcentrate
2. dissolutionDissolve the residue in NaHCO3 (10 mL)
3. extractionExtract the aqueous layer two times with 10 mL of CH2Cl2
4. dry with materialDry the organic layer over Na2SO4
5. filtrationfilter
6. concentrationconcentrate
7. customPurify the crude material by chromatography