Acetic Acid → 2-Bromo-6-piperidin-1-ylmethylpyridine

HRID 167273Notes

Reaction equation

HRID 167273 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH:8]=[O:9])[n:7]1.[C:20]([O:21][BH-:22]([O:23][C:24](=[O:25])[CH3:26])[O:27][C:28](=[O:29])[CH3:30])(=[O:31])[CH3:32].[C:34](=[O:35])([O-:36])[OH:37].[CH2:10]1[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.[CH3:16][C:17](=[O:18])[OH:19].[Cl:39][CH2:40][Cl:41].[Na+:33].[Na+:38]>>[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH2:8][N:13]2[CH2:12][CH2:11][CH2:10][CH2:15][CH2:14]2)[n:7]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 6344DichloromethaneHCID 8082PiperidineHCID 2724942TriacetoxyborohydrideHCID 27570096-Bromopyridine-2-carbaldehyde

Product 1

HCID 137845442-Bromo-6-piperidin-1-ylmethylpyridine

Sources & evidence

ORD record
ord-86422cf7d845446993a905b7e5e95299
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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