反应详情

3-Iodobenzohydrazide (500 mg, 1.91 mmol) obtained in Step 1 was dissolved in DMF (3.8 mL), and the mixture was stirred at room temperature for 10.5 hours after adding pyridine (0.231 mL, 2.86 mmol) and propionyl chloride (0.183 mL, 2.10 mmol) at 0° C. Water was added to the mixture, stirred, and the precipitated solid was filtered off and dried to give 3-iodo-N′-propionylbenzohydrazide (400 mg, 66%).

1. stirringstirred
2. filtrationthe precipitated solid was filtered off
3. customdried