Water → HCID 67350108, compound

HRID 1672781Notes

Reaction equation

HRID 1672781 reaction equation
[I:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH2:8])=[O:6].N1C=CC=CC=1.[C:18](Cl)(=[O:21])[CH2:19][CH3:20].O>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][NH:8][C:18](=[O:21])[CH2:19][CH3:20])=[O:6]

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 62324Propionyl chlorideHCID 6157743-Iodobenzohydrazide

Product 1

HCID 67350108HCID 67350108, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-Iodobenzohydrazide (500 mg, 1.91 mmol) obtained in Step 1 was dissolved in DMF (3.8 mL), and the mixture was stirred at room temperature for 10.5 hours after adding pyridine (0.231 mL, 2.86 mmol) and propionyl chloride (0.183 mL, 2.10 mmol) at 0° C. Water was added to the mixture, stirred, and the precipitated solid was filtered off and dried to give 3-iodo-N′-propionylbenzohydrazide (400 mg, 66%).

Workup

  1. stirringstirred
  2. filtrationthe precipitated solid was filtered off
  3. customdried

Sources & evidence

ORD record
ord-cd8239c13d134c1890a32fbc251c0b7d
Source dataset
uspto-grants-2011_08
Patent number
US07998954B2

Reaction notes

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