Hydrogen Bromide → HCID 136091536, compound

HRID 1673092Notes

Reaction equation

HRID 1673092 reaction equation
Br.[CH2:2]([C:6]1[CH:24]=[CH:23][C:9]([CH2:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([O:21]C)=[CH:18][CH:19]=3)[CH:14]=[CH:13][N:12]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5]>>[CH2:2]([C:6]1[CH:24]=[CH:23][C:9]([CH2:10][C:11]2[C:20]3[C:15](=[CH:16][C:17]([OH:21])=[CH:18][CH:19]=3)[CH:14]=[CH:13][N:12]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 59715638HCID 59715638, compound

Product 1

HCID 136091536HCID 136091536, compoundYield 94.6%

Procedure

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

Workup

  1. temperatureunder reflux for 19 hours
  2. concentrationThe mixture was concentrated under reduced pressure, water
  3. additionwas added
  4. customto precipitate crystals
  5. filtrationThe obtained crystals were collected by filtration
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-b7994a8bf2444da5a54afa15b9f4c8c1
Source dataset
uspto-grants-2011_08
Patent number
US07999090B2

Reaction notes

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