Benzylamine → (7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrile

HRID 1673181Notes

Reaction equation

HRID 1673181 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH2:9][C:10]2=O)=[CH:5][CH:4]=1.[C:14]([CH2:16]C(O)=O)#[N:15].C(O)(=O)CCCCCC.C(N)C1C=CC=CC=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][CH:9]=[C:10]2[CH2:16][C:14]#[N:15])=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 7504BenzylamineHCID 8094Heptanoic AcidHCID 9740Cyanoacetic acidHCID 812767-Methoxy-1,2,3,4-tetrahydronaphthalen-1-one

Product 1

HCID 11287102(7-Methoxy-3,4-dihydronaphthalen-1-yl)acetonitrileYield 90%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

There are introduced into a 670 liter reactor 85.0 kg of 7-methoxy-1-tetralone, 60.3 kg of cyanoacetic acid and 15.6 kg of heptanoic acid in toluene in the presence of 12.7 kg of benzylamine. The mixture is heated at reflux. When all the starting substrate has disappeared, the solution is cooled and filtered. The precipitate obtained is washed with toluene and then the filtrate obtained is washed with a 2N sodium hydroxide solution and subsequently with water until neutral. After removal of the solvent by evaporation, the resulting solid is recrystallised from an ethanol/water (80/20) mixture to give the title product in a yield of 90% and with a chemical purity exceeding 99%.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux
  3. temperaturethe solution is cooled
  4. filtrationfiltered
  5. customThe precipitate obtained
  6. washis washed with toluene
  7. customthe filtrate obtained
  8. washis washed with a 2N sodium hydroxide solution and subsequently with water until neutral
  9. customAfter removal of the solvent
  10. customby evaporation
  11. customthe resulting solid is recrystallised from an ethanol/water (80/20) mixture

Sources & evidence

ORD record
ord-3ab464db361645408993dc375c009403
Source dataset
uspto-grants-2011_08
Patent number
US07999129B2

Reaction notes

Loading…