反应详情

温度

50 °C

To a mixed solution of 30 ml of methanol and 30 ml of an aqueous 15% sodium hydroxide solution, 19 g of the obtained 2-chloro-5-fluoro-4-(2-propynyloxy)benzoic acid 2-propynyl ester was added, followed by stirring at 50° C. for 2 hours. The reaction mixture was acidified by adding hydrochloric acid and the obtained solid was collected by filtration. The solid was washed with a mixed MTBE-hexane solvent, and 10 g of 2-chloro-5-fluoro-4-(2-propynyloxy)benzoic acid was obtained.

1. filtrationthe obtained solid was collected by filtration
2. washThe solid was washed with a mixed MTBE-hexane solvent