反应详情

温度

45 °C

To a mixture of 2.1 g (6.3 mmol) of 4′-tert-butyl-2,5-dimethylbiphenyl-4-amine in 2.5 ml methanol a solution of 8.8 mmol of N-(dimethoxymethyl)-N-methylethanamine (60% in methanol) was added. The reaction mixture was stirred for 24 hrs at 45° C. The reaction mixture was concentrated in vacuo. Column chromatographic (gradient: cyclohexane->ethyl acetate) yielded 0.96 g (3.0 mmol) 47% of N′-(4′-tert-butyl-2,5-dimethylbiphenyl-4-yl)-N-ethyl-N-methylimidoformamide; log P (pH 2.3)=2.67.

1. additionwas added
2. concentrationThe reaction mixture was concentrated in vacuo